New scientific article published
supplementation of hexanoic acid together with the overexpression of acyl-activating enzyme 1 from C. sativa (CsAAE1 ) to provide hexanoyl-CoA. Here, we implement a heterologous OA biosynthesis pathway into [...] from Penicillium chrysogenum (PcPCL-K ) which displayed superior hexanoyl-CoA ligase activity to CsAAE1 . Together, these strategies enabled the production of 180 mg/L OA using shake flask cultures. Our results …